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(Update 1 week ago)

JERUSALEM (AP) — Palestinian worshippers clashed with Israeli police late Friday at the Al-Aqsa mosque compound, a major holy site sacred to Muslims and Jews, in an escalation of weeks of violence in Jerusalem that has reverberated across the region.

The Palestinian Red Crescent emergency service said 136 people were wounded in clashes with police there and elsewhere in Jerusalem, including 83 who were hospitalized. It says most were wounded in the face and eyes by rubber-coated bullets and shrapnel from stun grenades. Israel said six police officers were wounded.

Earlier Friday, Israeli troops shot and killed two Palestinians and wounded a third after the men opened fire on a base belonging to Israel’s paramilitary Border Police force in the occupied West Bank, the latest in a series of deadly confrontations in recent weeks that has coincided with the Muslim holy month of Ramadan. More unrest appears likely next week.

Tensions have soared in recent weeks in east Jerusalem, which is claimed by both Israel and the Palestinians. At the beginning of the Muslim holy month of Ramadan, Israel blocked off a popular gathering spot where Palestinians traditionally socialize at the end of their daylong fast. The move set off two weeks of clashes before Israel lifted the restrictions.But in recent days, clashes have resumed due to Israel’s threatened eviction of dozens of Palestinians in the Sheikh Jarrah neighborhood in east Jerusalem, who have been embroiled in a long legal battle with Israeli settlers trying to acquire property in the neighborhood.

The United States said it was “deeply concerned” about the heightened tensions and called on all sides to work to de-escalate them. It also expressed concern about the threatened evictions.

“It’s critical to avoid unilateral steps that would exacerbate tensions or take us further away from peace. And that would include evictions, settlement activity, and home demolitions,” U.S. State Department spokeswoman Jalina Porter told reporters in Washington.

The Al-Aqsa mosque compound is the third holiest site in Islam. The site is also the holiest site for Jews, who refer to it as the Temple Mount and revere it as the spot where the biblical Temples stood. It has long been a flashpoint for Israeli-Palestinian violence and was the epicenter of the 2000 Palestinian intifada, or uprising.

Israeli police deployed in large numbers as Muslim worshippers were holding evening prayers at the site. It was unclear what sparked the violence, but videos circulating online showed worshippers throwing chairs, shoes and rocks at police, who fired stun grenades and rubber-coated bullets to disperse them. Smaller clashes broke out elsewhere in Jerusalem.

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